Sexuálne prenosné ochorenia

Odborníci z radov gynekológov a dermatovenerológov varujú pred výrazným nárastom výskytu genitálnych bradavíc, sexuálne prenosného ochorenia, ktoré napáda rovnakou mierou ženy i mužov.

hpv_ilu_422

Výskyt tohto ochorenia, ktoré spôsobuje infekcie ľudskými papilomavírusmi (HPV), sa za posledné roky zniekoľkonásobil. Ide o vysoko infekčné ochorenie, ktoré veľa pacientov podceňuje a včas nelieči, hoci je na Slovensku k dispozícii účinná ambulantná i domáca liečba.

FAKTY A ČÍSLA

Infekcia HPV

- Ľudské papilomavírusy (human papillomavirus = ľudský papilomavírus) sú skupinou vírusov napádajúcich kožu a sliznicu človeka, hlavne v oblasti genitálií a konečníka.

- Popísaných je viac ako sto rôznych typov. Nákazu niektorými z nich sprevádzajú vysoké zdravotné riziká.

- V súčasnosti je HPV najčastejšia sexuálne prenosná infekcia.

- Za život sa s ňou stretne 80 % sexuálne aktívnych mužov aj žien.

- Najčastejšie sa nakazia ľudia vo veku 18 až 25 rokov.

- Pokiaľ sa organizmus infekcie nezbaví, môže dôjsť ku zdravotným komplikáciám alebo dokonca k rozvoju vážnych ochorení. Odhadnúť, u koho sa choroba prejaví, nie je možné.

-  Symptómy ochorenia sa môžu objaviť až niekoľko rokov po nákaze a je teda skoro nemožné určiť, kedy ku nákaze došlo.

- Kondóm znižuje riziko prenosu, ale nie je 100% ochranou.

- Infekcia sa prenáša aj maznaním a orálnym sexom.

- Infikovaná osoba väčšinou nemá žiadne príznaky a nevie, že je prenášačom vírusu.

HPV ochorenia

- Typy vírusov s vysokým rizikom (hlavne 16 a 18) majú na svedomí zhubné ochorenia: nádory a závažné prednádorové stavy v oblasti krčka maternice, vonkajších rodidiel, pošvy, penisu, konečníka a tiež hlavy a krku.

- Typy vírusov s nízkym rizikom (hlavne 6 a 11) spôsobujú: condylomata acuminata (genitálne bradavice, kondylómy), papilomatózu hrtana, menej závažné prednádorové stavy.

Rakovina krčka maternice je najčastejšie onkologické ochorenie spôsobené infekciou HPV. Rakovina krčka maternice vzniká v priemere po pätnástich rokoch od infekcie vysoko rizikovým typom HPV.

Genitálne bradavice sú najčastejšie ochorenie vôbec spôsobené infekciou HPV. Vývoj od infekcie po vznik kondylómov trvá väčšinou niekoľko týždňov.

- Výskyt genitálnych bradavíc a papilomatózy hrtana v posledných rokoch prudko stúpa.

Genitálne bradavice

- Genitálne bradavice (kondylómy, condylomata acuminata) sú nezhubným (benígnym)  ochorením vírusového pôvodu. Spôsobujú ich tzv. HPV vírusy (Human Papillomae Virus - ľudský papilomavírus).

- Klinicky ide o kožné výrastky, ktoré zvyčajne vznikajú v oblasti vonkajších pohlavných orgánov, a to tak u žien, ako aj u mužov. Veľmi často sú belavej alebo pleťovej farby, môžu však byť aj tmavo sfarbené. Veľkosť genitálnych bradavíc sa pohybuje od úplne malých, voľným okom sotva viditeľných bradavičiek, až po útvary karfiolového tvaru.

- U žien sa najčastejšie vyskytujú okolo pošvového vchodu, môžu však vznikať aj v pošve a na krčku maternice. Okrem nepríjemných vonkajších prejavov znamenajú pre ženu veľmi často aj obmedzenie sexuálnej aktivity a následnú možnosť vzniku depresií. U tehotných žien môže dôjsť aj k prenosu tohto vírusu na plod v priebehu pôrodu a následne spôsobiť u dieťaťa výskyt tzv. papilomatózy hrtana, ktorá môže ohroziť život dieťa udusením.

- U mužov sa genitálne bradavice objavujú najčastejšie na penise alebo miešku. Taktiež môžu byť okolo konečníkového otvoru, v priestore medzi genitáliami a konečníkom, na tzv. hrádzi. Vzácne sa vyskytujú v oblasti slabín. Môžu byť príčinou ďalších ochorení, akým je napríklad fimóza, ďalej chronických zápalov močovej trubice vrátane bolestivosti v mieste výskytu.

- Infekcia sa môže preniesť prostredníctvom drobných poranení sliznice infikovaného partnera, a to počas pohlavného styku (vaginálneho, orálneho aj análneho). Ide teda o sexuálne prenosné ochorenie. Infekcia sa môže prejaviť klinicky, teda vznikom bradavíc, ale aj nie, aj keď je človek vírusom infikovaný.

- Genitálne bradavice postihujú najmä ľudí v období aktívneho sexuálneho života. Odhaduje sa, že na svete sa vyskytne viac než 6 miliónov nových infekcií u ľudí vo veku 14 – 44 rokov. V USA sa diagnostikuje viac ako 1 milión nových prípadov genitálnych bradavíc ročne.

-  Aj keď genitálne bradavice nie sú smrteľne nebezpečné, predstavujú pre pacientov značnú zdravotnú, psychosociálnu a ekonomickou záťaž.

 

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    Creatine Monohydrate is usually suggested to take a complete of
    three to five grams for better efficiency and muscle growth.
    Nicely, some individuals also contribute creatine loading phase,
    in their bulking cycle. Creatine Monohydrate is probably one of the most extensively researched and confirmed dietary supplements that deliberately
    enhance efficiency.
    Creatine has demonstrated neuromuscular efficiency
    enhancing properties on brief duration, predominantly anaerobic, intermittent workout routines.
    Creatine supplementation could facilitate the reuptake of Ca2+ into the sacroplasmic reticulum by the action of the Ca2+ adenosine triphosphatase pump, which could
    allow drive to be produced extra quickly through the
    faster detachment of the actomyosin bridges. For safety, once more with limited research on HCL compared to
    creatine monohydrate, it would be onerous to go along with monohydrate given that it's the
    most pure form of creatine. Masses of research have pointed to monohydrate being
    a protected and efficient kind, and whereas HCL might very well be the same or better, we just don’t have the proof yet to make that solid declare.

    For those trying into total effectiveness, your greatest bet is
    to go along with monohydrate since so many research are on the market.
    With plenty of analysis, creatine monohydrate has been proven to increase strength, restoration, and
    work to construct that muscle you need to
    see most.
    Analysis that zeroes in on creatine hydrochloride is so limited, it's onerous to
    say for sure that the advantages really make it more practical.
    The problem is, there isn't enough research to say
    for certain that creatine HCL is the better than creatine monohydrate so far as absorption. The Worldwide Society of Sports Nutrition is
    on board with using a creatine complement as properly. In their place stand, they state that long and short-term creatine
    use is protected and well-tolerated by typically wholesome individuals.

    Degree of proof for the position of creatine supplementation in individuals with psychological problems.
    Degree of evidence for the role of creatine supplementation in individuals
    with neurodegenerative issues. Stage of proof for the position of creatine supplementation in individuals with traumatic and ischemic CNS accidents.

    Initially thought to be purely a psychological problem, linking fatigue to despair or other psychiatric illnesses, newer research has been in a place to show a metabolic dysfunction causing the symptoms
    [99,260,261]. Linking this scientific state with mitochondrial dysfunction was first
    in a position when lowered mitochondrial ATP ranges have been shown using MRS
    on sufferers with fatigue syndrome [262]. Later muscle biopsies and serum biomarkers have
    been able to present reduced mitochondrial biomarkers [263,264].

    Though there may be much less research available on creatine HCL compared to monohydrate, preliminary studies and anecdotal evidence recommend that it might require a lower dosage to attain comparable advantages because of its enhanced absorption rates.

    You could be pondering, ‘these advantages sounds compelling’, and you’d be
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    its security profile and long-term effects on muscle development and efficiency, has been conducted using creatine monohydrate.
    Consequently, whereas Creatine HCL presents an intriguing different,
    particularly for individuals who may not tolerate monohydrate nicely, the
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    By replenishing ATP ranges more effectively, creatine
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    This translates to significant improvements in energy, power output, and muscle endurance, which can help you push more
    durable during workouts and get well faster between sets (Wu, S et al., 2022).


    With so many various forms of creatine, it’s important to seek out the proper
    type to deliver the most effective outcomes. Creatine hydrochloride, very comparable to Kre-Alklayn is a sophisticated form of creatine and has turn into a outstanding option when it
    comes to creatine dietary supplements. Nevertheless, research have proven that the
    majority superior types of creatine don’t produce any
    higher outcomes than creatine monohydrate. We’re going
    to speak more concerning the variations and the science about creatine HCL
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    There are lots of of peer-reviewed research on the effectiveness and safety surrounding
    taking creatine monohydrate. Similar to creatine supplements, creatine monohydrate is synthetic or man-made.

    Creatine isn't solely secure, however it’s some of the well-liked
    and efficient dietary supplements utilized by athletes to increase energy and muscle.

    Publication of those findings should not be considered as endorsement by the investigators or their institutions of the vitamins
    investigated. The really helpful dosage is 3-5 grams per day, sometimes split earlier than and after workouts.
    Anticipate expert-backed exercises, nutrition recommendation, the most
    recent in energy sports activities, and a complete lot of motivation heading your method.
    Keep in mind that creatine is greatest taken with easy carbohydrates,
    corresponding to glucose. It might due to this fact dissolve powder in fruit juice or swallow capsules with carbohydrates to
    reinforce the effect of creatine and decrease harm.

    Resistance train training increased follistatin expression within the gastrocnemius white portion (Figure
    6A) and soleus muscle tissue (Figure 7A). Gastrocnemius follistatin expression was higher in Tc than in the
    Cc and Tcr groups (Cc zero.forty five ± zero.sixteen; Cr zero.40 ± 0.17, Tc zero.eighty two ± zero.33,
    Tcr 0.52 ± zero.27 arbitrary items; Figure 6A). Both educated teams offered lower gastrocnemius
    myostatin levels than their respective controls (Cc 1.27 ± zero.32; Cr 1.32 ± zero.17, Tc zero.76 ±
    0.22, Tcr 0.88 ± zero.thirteen arbitrary units; Figure 6B).


    Although the complement is definitely digestible combining it with food will improve its efficacy and could be absorbed higher.
    Creatine monohydrate is amongst the most typical additions
    in bodybuilding supplementation. Athletes and powerlifters
    usually contribute to creatine monohydrate to emphasise their performance.

    Finally, the merit of taking creatine HCl over monohydrate
    is that a significantly lower dose of the previous
    can elicit ergogenic results commensurate to a larger dose of the latter.
    Therefore, the HCl kind will be the better choice
    for individuals who expertise gastrointestinal discomfort
    from consuming performance-enhancing doses of creatine monohydrate.

    Therefore, creatine transporter discussion through the the
    rest of this manuscript will discuss with CreaT1 as CreaT, since
    muscle fibers are of the larger focus. "Despite the known efficacy, safety, and low value of creatine monohydrate; a variety of different types of creatine have been marketed as simpler with fewer anecdotally reported opposed results. Theoretically, creatine Hcl can be just as efficient (or even more) as creatine monohydrate when it comes to increasing adenosine triphosphate in your muscle cells, because of probably being simpler to soak up. The connected hydrochloric acid in this sort of creatine complement also makes the molecule more stable. It also means you might have the ability to skip the loading section and nonetheless see results. No matter what, be certain to continue creatine supplementation even on rest days.
    This implies that most of creatine’s useful effects, corresponding to improved higher and lower physique train efficiency, have been observed virtually completely when creatine monohydrate was used (15, 16). Regardless of the shape, creatine complement has proven to increase energy, construct fat-free mass, and muscle morphology with heavy resistance training. The Worldwide Society of Sports Activities Nutrition states that the quickest method to improve creatine muscle stores is by consuming 0.three grams of creatine per kilogram of physique weight for 5 to seven days, adopted by 3 to 5 grams of creatine per day. During the initial dosing phase, it could must be damaged up into smaller portions throughout the day to keep away from attainable abdominal side effects, corresponding to diarrhea. Including the initial dosing session, one portion of the dose ought to be consumed with carbohydrates 30 minutes before a exercise or instantly after a workout.
    Creatine HCL is a extra recent form; therefore it's expensive when in comparison with monohydrate form. If you may be simply starting out with these dietary supplements, then go for creatine monohydrate. Creatine may benefit in other modes of train, such as high-intensity sprints or endurance coaching (11).
    As such, if you persist with the upkeep dose from the get-go, you’re more more doubtless to keep away from any annoying signs. Mitochondrial function and ATP production are essential for the neuronal survival and excitability [193]. At the same time, nevertheless, mitochondrial dysfunction leads to the overproduction of ROS and neuronal apoptosis which is closely associated to neurodegenerative illnesses and cerebral ischemia [193,194,195,196,197].
    This type of creatine may
look cool as it foams up in your shaker, but it supplies no higher absorption than common creatine monohydrate. If you're in search of proven effectiveness and cost-efficiency and don't thoughts the potential for delicate bloating or a loading part, Creatine Monohydrate might be your go-to. On the opposite hand, should you favor a complement that could be gentler in your stomach and don't mind paying a bit extra for the convenience of a decrease dose, Creatine HCL could probably be price exploring. While numerous creatine options exist in the market, success lies in selecting the kind that finest aligns with individual wants and preferences.
    Moreover, some analysis in cell tradition has indicated that combining creatine and sodium may additionally improve creatine uptake through the manipulation of increasing the gradient in which the CreaT capabilities [27]. The current literature may be very preliminary in relation to analyzing how creatine supplementation impacts CreaT expression while concomitantly following a resistance training protocol. Earlier research has concluded that there isn't any gender distinction within the complete creatine content in muscle, either earlier than or after supplementation. Though this suggests that CreaT exercise is unlikely to vary between genders, no analysis has instantly investigated this. Murphy et al. chose to focus upon whether or not there's a distinction between genders in CreaT mRNA and protein in healthy, younger adults [21].
    As A Result Of creatine plays a significant role on this system, more creatine means more potential ATP, which interprets into improved efficiency on short-duration, high-intensity duties. As A End Result Of long-duration, low-intensity actions rely extra on a different vitality system, they don't appear to be usually enhanced by creatine — in different words, creatine will help a sprint but not a marathon. Almonds are full of protein and creatine producing arginine, which helps in the development of lean muscle mass. They also contain wholesome fat which assist in sustaining and reducing the general physique mass index, making you shed weight (28).
    The findings of this study spotlight the significance of considering supplementation of creatine monohydrate when present process testing for the maximal glycolytic price. When contemplating the addition of supplements such as creatine monohydrate or creatine phosphate to your routine, it's essential to hunt steering from health professionals. They can provide customized recommendation based mostly in your health standing, dietary wants, and health objectives. A sports activities nutritionist or a dietitian can supply insights into how these supplements could be built-in into your overall vitamin plan. Creatine phosphate, also recognized as phosphocreatine, is a naturally occurring substance inside muscle cells.
    This allowed for the assessment of acute and persistent supplementation protocols on muscle creatine ranges, body composition, train performance, in addition to markers of clinical health and safety. Participants were requested to take care of their current training applications and document all workouts. Creatine monohydrate (CrM) has been constantly reported to extend muscle creatine content and improve high-intensity train capacity.
    Creatine is a naturally occurring molecule within the body produced from the amino acids glycine, arginine, and methionine. The majority of creatine is made within the liver, and a few in the kidneys and pancreas. Creatine performs a major function in vitality manufacturing, especially beneath conditions of excessive demand, such as physical exercise.
    However, in case you are in search of a more soluble type of creatine, nitrate should be your most popular alternative. It has a faster absorption price which may comparatively influence faster outcomes as compared to monohydrate. On the opposite hand, creatine monohydrate stays the gold normal in analysis, with more-than-enough scientific evidence backing its efficacy and security. Since Creatine HCl remains to be a comparatively new sports activities supplement, much less research has been performed on it.

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    So, you need to try to add somewhat weight or maximize the
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    lifting for hypertrophy days as properly. For the bulking program
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    If you are too skinny, then it is obvious you want to continue your
    bulking routine. If you are too fats, you then want to cease bulking and start chopping.
    Even extra so than weightlifting will increase, we don't discover
    the change in our bodies from understanding because we see ourselves
    on an everyday basis. Taking footage each month
    or two is great motivation and reference information. Nitric Oxide
    has been just lately getting lots of promotion in the media for a fantastic supplement, and for the great causes.

    Begin these together with your elbows pointing immediately up at the ceiling to keep the give consideration to the triceps.
    The professional bodybuilder is arguably essentially the most aesthetic
    man on the planet. For the primary time in decades, the lifting community has a champion bodybuilder to aspire to look like.
    And whereas we may not be capable of replicate his actual results,
    we will certainly study a thing or two from how Chris Bumstead trains.
    Skull crushers are an necessary a half of
    building a a lot bigger bench press. When you finish them, you ought
    to use the same setup for doing pullovers. The magic of a Bro Cut Up is how today overlap with one another.


    Of course, even with that, you won’t get
    newbie gains ever once more without the usage of steroids.

    Now, that being stated, the higher end may also come with more fats
    achieve. Anyone who says they put on like 20lbs of muscle in 2 months did not (unless they are taking steroids
    or sarms). Simply because the size says 20lbs doesn’t mean it's muscle.
    It really depends on your health degree, age, how long you're bulking, and your workouts, amongst other components.

    In such instances, the proper supplement can be a lifesaver.
    That being stated, choose dietary supplements might help you reach your
    objectives sooner and, in some cases, provide you with further benefits.
    The squat is commonly known as the king of all workouts for good
    reasons. Sadly, there is no "best" program for bulking.
    On the contrary, they can be very helpful for fueling your muscular
    tissues (and brain) and making your bulk more productive.
    After accounting for your fat energy, you've 1,580 energy left to play with.
    In different words, your every day protein goal might be round 180 grams.

    Progress drives muscle progress, and muscle growth drives progress.
    Coaching six days per week takes plenty of vitality,
    so you’ll have to consume a calorie excess to gasoline your workouts, restoration, and muscle growth.
    Begin by assessing your one-rep max (1RM) for key compound lifts such
    because the squat, deadlift, and bench press. Evaluating these numbers to
    your beginning 1RM highlights the strength features made throughout
    the year. Additionally, measure your physique composition using
    tools like calipers or physique scans to discover out adjustments in muscle mass and fats proportion. Having a clear
    and structured workout plan is important when aiming to bulk successfully.
    It ensures consistent muscle stimulation and helps track progress over time.

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