Nádory tenkého čreva patria medzi zriedkavé

Napísal TS OZ Zriedkavé choroby 30. apríl 2020

Tretia časť osvetového videoseriálu o TOP slovenských pracoviskách pre zriedkavé choroby predstavuje Oddelenie klinickej onkológie E, ktoré patrí pod II. Onkologickú kliniku LFUK a NOÚ. Viac ako 20 rokov sa venuje liečbe nádorov tráviaceho traktu, malígneho melanómu a tiež pľúc a hrudníka.

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Aj keď sa oddelenie, kde ročne hospitalizujú vyše 1 100 pacientov z celého Slovenska, primárne zameriava na liečbu nádorov zažívacieho ústrojenstva, ktoré patria v onkológii k najčastejším, i tu sa stretávajú s raritnejšími diagnózami. „Ide najmä o karcinómy pažeráka, tenkého čreva, análneho kanála, vzácne formy rakoviny pečene, nádory pohrudnice, melanómy oka, ale tiež neuroendokrinné nádory, ktoré môžu postihnúť akýkoľvek orgán. Kľúčom k ich diagnostike sú moderné genetické vyšetrenia, ktoré prispeli k účelnejšej klasifikácii nádorov a tým aj k cielenejšej liečbe,“ hovorí primár oddelenia MUDr. Jozef Dolinský.

Kým štatistiky nádorových ochorení tráviacej sústavy neslávne vedie hrubé črevo, a to ako na Slovensku tak i v Európe, susediace tenké črevo, kde prebieha najdôležitejšia časť trávenia, je na tom z pohľadu výskytu opačne. Nádory tenkého čreva patria k zriedkavým, predstavujú zhruba 1 až 2% všetkých nádorov zažívacieho traktu. Ročne je v NOÚ diagnostikovaných približne 60 pacientov.

V súčasnosti veľmi významne stúpa aj výskyt nádorov pankreasu, ktoré patria k mimoriadne zákerným ochoreniam, aj kvôli tomu, že z dôvodu dlhej bezpríznakovosti sa často diagnostikujú až v pokročilých štádiách. K zriedkavým diagnózam tu patria neuroendokrinné nádory, ktoré v porovnaní so štandardnými adenokarcinómami pankreasu majú ale oveľa priaznivejšiu prognózu. „Mali sme tu napríklad pacienta diagnostikovaného v 54. roku života, ktorý v súčasnosti prežíva s diagnózou neuroendokrinného nádoru pankreasu 14-ty rok,“ vysvetľuje klinická onkologička z oddelenia, MUDr. Silvia Jurišová.

O charaktere nádoru pankreasu ako žľazy s vonkajším - exokrinným a vnútorným - endokrinným vylučovaním rozhoduje typ buniek, z ktorého je zhubný nádor tvorený. Neuroendokrinné nádory vznikajú z endokrinných buniek, ktoré majú na starosti produkciu hormónov ako napríklad inzulín ovplyvňujúci hladinu cukru v krvi. Štandardné adenokarcinómy (zhubné nádory buniek výstelkového tkaniva) pankreasu vznikajú z exokrinnej časti, ktorá tvorí 95% pankreasu a je zodpovedná za tvorbu pankreatickej šťavy napomáhajúcej tráveniu.

Pre akýkoľvek typ nádoru, pri zriedkavých diagnózach o to viac, je kľúčová diagnostika. Na pomoc jej v posledných rokoch okrem patológie prichádzajú moderné genetické metódy, ktoré zásadným spôsobom menia klasifikáciu nádorov. Inak povedané, kým sa jednotlivé nádory kedysi definovali podľa časti tela, orgánu alebo neskôr bunky, z ktorej vychádzali, moderná genetická diagnostika ide hlbšie do vnútra bunky, až na úroveň génov. Výsledkom je zacielenie liečby na časť DNA, ktorá spustila nádorové bujnenie a to v kontexte liečby posúva medicínu o výrazný krok ďalej.

Pozrite si tretiu časť videoseriálu TOP pracoviská pre zriedkavé choroby, ktoré pripravuje OZ Zriedkavé choroby. V seriáli sú postupne predstavované slovenské pracoviská a špičkoví odborníci. https://www.zriedkavechoroby.sk/kde-hladat-pomoc/videoserial-top-pracoviska/

Seriál je prístupný aj na YouTube kanáli OZ Zriedkavé choroby:


 Kto je OZ Zriedkavé choroby:

Občianske združenie Zriedkavé choroby odštartovalo svoju činnosť v roku 2018. Špecializuje sa na zriedkavé choroby, ktorými môže na Slovensku trpieť až 300-tisíc Slovákov. Na svojom portáli www.zriedkavechoroby.sk ponúka komplexné informácie, aktuality, zoznamy odborníkov a špecializovaných pracovísk, odborných zahraničných zdrojov a platforiem. Na portáli sa nachádza pravidelne aktualizovaná podstránka skutočných pacientskych príbehov, s opismi príznakov chorôb. Združenie poskytuje pacientom a ich blízkym poradenstvo, pomoc a tiež služby krízovej intervencie.

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    The hack squat is a sort of squat that is carried
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    Not all knee sleeve manufacturers use the identical measurement method, so it’s important to comply with
    their specific directions. Knee sleeves geared towards lifting are usually made
    with neoprene or an SBR/neoprene blend. SBR,
    which stands for Styrene-Butadiene Rubber,
    is a synthetic materials with wonderful abrasion resistance
    and getting older traits. The 7mm thickness is compressive and supportive for powerlifting and more.
    Rehband has been a outstanding participant in the knee
    sleeve sport for many years.
    In fact, they give you a replacement if the knee braces you bought aren’t
    snug for you. Knee sleeves supply compression and assist that
    can enhance blood move, stabilize the knee joint during movement, and reduce discomfort.
    This compression increases blood flow to the
    world, which might reduce pain, and swelling, like from knee effusions, or fluid buildup within the bursa of the knee joint.

    In Distinction To most knee sleeves, Bauerfeind Sports Activities Knee Help comes with a built-in patellar pad.

    This padding surrounds the kneecap, helping keep it
    in place and distributing pressure evenly to the encompassing muscles.
    The knit design permits for four-way stretch, which makes
    this sleeve extra comfortable. It’s made from a mix of spandex, nylon, and latex, which permits for breathability — especially crucial during workouts.
    This knee sleeve is presently out there in sizes small by way of extra-extra-extra-large.

    Meanwhile, there's no need to fret about overheating—this knee
    sleeve is simply as breathable, moisture-wicking, and quick-drying as any other on this record.

    JIUFENTIAN Copper Knee Brace, featuring silicone rings for stability and high-density copper-infused knit, is in style for offering excellent knee help.
    Ideal for sports activities, restoration, and daily actions, it meets a selection of wants.
    Sleek and ergonomic, the sleeve presents versatility for various
    body sizes and shapes. Made from a extremely tuned 4-way
    stretch materials, the PowerLix Knee Sleeve provides a snug yet soft fit for full knee mobility whereas decreasing injury risk.
    This 6mm thick fabric balances compression and flexibility, good for health club moves and WODs.

    They will maintain your knees warm however will not help the knee joint, reduce joint ache beneath important load,
    or let you carry extra weight. For one, knee sleeves are a lot
    easier to slip on and off, whereas knee wraps require you to spend extra time properly encasing the joint in a wrap
    job that’s efficient and durable. Moreover, knee sleeves are more accommodating to other
    movements — when carrying knee sleeves, you’re nonetheless able
    to walk around or perform dynamic workout routines relying on thickness.
    Knee wraps are designed for max tightness, primarily maintaining your legs in a
    straight place until under a heavy squat. This also can make for a much less comfy coaching expertise
    should you go away the accessory on all through your whole workout.
    Yes, knee compression sleeves work nicely if you buy a quality product and
    use the correct measurement. Knee compression sleeves will
    help present some gentle support, hold your joints warm, enhance blood move, and help in serving
    to you recover quicker.
    This can indirectly result in better train performance,
    serving to you attain train targets sooner. Knee Wraps Vs.
    Sleeves – The choice between knee wraps vs.
    sleeves comes all the method down to exercise goals.
    Wraps act as a spring increase to your carry, useful
    in both weightlifting & powerlifting for pulling off heavy lifts
    or growing your 1RM (one-rep max). Sleeves add warmth and compression to the joint,
    making lifts safer and extra stable. These 7mm neoprene knee sleeves have silicone grips
    to keep them firmly in place. The thick neoprene material is stretchy and supportive, they're well-made, plus they've a
    contoured design to ensure a snug match. At 29cm
    lengthy, they're among the largest in the marketplace,
    providing broad compression on and around the joint.
    Rogue is understood for making some of the highest-quality fitness gear, and these sleeves hit the mark.
    These sleeves are manufactured from a 3D woven Air Knit materials that will not aggravate
    sensitive skin like some other knee braces available on the market.
    Plus they included non-slip gel strips to help keep away
    from the sleeve from sliding down or bunching up.

    These sleeves might help beat back knee discomfort from tendonitis or damage recovery.

    Designed for regular utilization, you'll find a way to put on this knee compression sleeve for long hours with out feeling
    any chafing or itching. This must be a great option for those who’re only on the lookout for a temporary knee sleeve to use and abuse.
    It’s low-cost, comfy, and provides great compression for
    a somewhat limited time.
    The Mava Sports Knee Sleeve is great for lively sports activities
    and daily put on. Essential Compression knee
    sleeves are simple, affordable, but in addition very
    effective. Nordic Lifting Knee Sleeves is a brand
    trusted by lots of of lifters. We’re speaking weightlifters, crossfitters, powerlifters, and all other heavy lifting sports.
    Another factor that makes it great for the thicker population is that it’s
    straightforward to put on.
    If you endure from knee ache you can even put on these all day
    lengthy whenever you're out and about to supply ache aid.
    We chose the Stoic sleeves as one of the
    best knee sleeves for squats though you can use them for
    nearly any athletic pursuit. With the almost countless
    options in the marketplace, we decided it would be helpful to chop by way of the fog to search out
    you the 9 finest knee sleeves available on the market right now.
    It is made for longevity, with high-performance compound cloth and double stitching.

    The inner layer is constructed independently of the outer layer, which ensures that no
    matter how rough you employ the knee brace, it'll proceed to provide high
    quality compression. Heat, chilly, and compression are normal care
    procedures for all phases of knee harm restoration, prevention, and most (if not all) types of activity.
    Dr. Greg Minnis, a bodily therapist at Excel Physical Therapy in New Jersey, says you wish
    to be sure that the sleeve is not so tight that it causes discomfort.

    Simply slide your foot contained in the brace, pull it up over your
    knee, and you’re good to go. Nonetheless, it can get barely uncomfortable if worn for a
    very long time due to the heat and stitching on the back.
    We additionally included quick critiques for every of them in addition to a short buyer’s guide.
    Notice that if you’ve skilled critical trauma
    to the knee, or are recovering from surgical procedure, you might need additional support than what a knee sleeve can supply.
    Seek The Advice Of with a doctor to ensure that
    a knee sleeve is right for you. If you sleep in your side,
    you may wish to look right into a small knee help pillow
    to advertise hip and spinal alignment. Low impression train also helps strengthen the muscle tissue round your knee,
    providing higher help.

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