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Mýty o užívaní liekov na zníženie koncentrácie cholesterolu

Napísal Prof. MUDr. Michal Vrablík, Ph.D. 16. máj 2019

Užívanie liečiv na zníženie koncentrácie cholesterolu a ďalších tukov v krvi (predovšetkým tzv. statínov) patrí medzi základné opatrenia pri prevencii infarktu myokardu, cievnej mozgovej príhody a ďalších ochorení zapríčinených aterosklerózou.

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V Slovenskej republike tieto lieky užíva viac ako milión pacientov, takže priamu alebo sprostredkovanú skúsenosť s nimi má takmer každý. V nasledujúcom texte sa pozrieme na niektoré „obľúbené“ omyly, ktoré sa udávajú v súvislosti s liekmi na znižovanie koncentrácie cholesterolu.

Koncentrácia cholesterolu po liekoch klesla, a preto ich môžem vysadiť

To celkom iste nie je pravda. Vysoká koncentrácia cholesterolu sa dá liečiť, ale nie celkom vyliečiť, pretože si pre ňu väčšinou nesieme genetickú (vrodenú) vlohu. Lieky fungujú len v prípade, že sú prítomné v organizme. Po prerušení liečby sa koncentrá- cie cholesterolu vracajú späť v priebehu niekoľkých dní. Preto treba lieky užívať trvalo.

Keď užívam statíny, nemusím dodržiavať zásady diéty

Ďalší obľúbený omyl. Diétne opatrenia pomáhajú nielen znižovať koncentráciu choles- terolu, ale upravujú aj ďalšie rizikové faktory aterosklerózy. Ich účinok sa vždy počíta a je prídavný k účinku liekov. Takže aj pre pacienta, ktorému lekár predpisuje tablety, má dodržiavanie diétnych a ďalších opatrení v oblasti životného štýlu zásadný význam.

Bojím sa vysokej dávky statínov

Obavy rozhodne nie sú na mieste. Dnes vieme, že vyššia dávka statínov chráni svoj- ho užívateľa účinnejšie ako dávka nižšia. Navyše väčšina (vzácnych) nežiaducich účinkov nemá priamu väzbu na dávku podávaného lieku a ich početnosť pri vyšších dávkach statínov nestúpa. Ak znášate dobre počiatočné dávky liekov, potom sa zvy- šovania dávky netreba obávať. Navyše, keď sa nežiaduci účinok po zvýšení dávky objaví, dá sa vrátiť k dávke pôvodnej alebo situáciu riešiť iným spôsobom.

Ak budem užívať statín dlhodobo, môže dôjsť k nepredvídaným nežiaducim účinkom

Skutočne chceme, aby statíny boli užívané dlhodobo; keď sa pre ne rozhodneme, ide o „doživotné“ rozhodnutie. Nie je však pravda, že by dlhší čas užívania prinášal riziká, súvisiace s dĺžkou liečby. Statíny používame viac ako 30 rokov a naďalej prebieha sledovanie ich bezpečnosti. Nemáme žiadne signály, že by dlhodobé užívanie statínov malo akékoľvek iné nežiaduce účinky ako tie, ktoré vzácne vznikajú pri krátkodobom užívaní.

Statíny sú nebezpečné

Zásadný omyl, bohužiaľ opakovaný v poslednom čase častejšie ako pravdy o priaz- nivých účinkoch týchto liekov. Statíny patria medzi vôbec najpreskúmanejšie liečivá a je pravdou, že ako všetky účinné liečivá majú aj nežiaduce účinky. Ich výskyt je však nízky a postihuje maximálne desatinu liečených. Väčšina z týchto nežiaducich účinkov je navyše plne vratných; v prípade, že sa objavia, vyriešime ich úpravou liečby. Hod- notenie bezpečnosti liečby patrí k bežnej praxi v rámci sledovania pacientov liečených statínmi, čo ďalej obmedzuje (veľmi nízke) riziko spojené s terapiou. Súhrnne statíny patria medzi najbezpečnejšie lieky a obavy nie sú na mieste.

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    This is a normal cycle we see amongst ladies for decreasing
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    The reverse can also occur, with steroids being able to inflicting early
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    On average, the normal range of testosterone in males is round 270 to 1070 ng/dl, nevertheless, ‘more genetically
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    Stripping fats is vital in phrases of increasing muscle definition and
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    Winstrol will increase LDL cholesterol levels and spike blood strain. We discover that orals are usually worse for the heart,
    as they stimulate hepatic lipase, with them being processed by way
    of the liver. This has a negative impact on ldl cholesterol, consequently impeding blood circulate.
    Girls who take Anavar do not sometimes experience masculinization under our care.
    Nonetheless, virilization is possible in massive doses or
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    Also, it might be sensible to restrict alcohol consumption when taking Anavar or
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    This may cause some stress on the liver, nevertheless, this impact is considered gentle,
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    In bodybuilding circles, many imagine Anavar to be the most secure
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    pressure, leading to acute renal injury (18). Approximately a decade
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    ldl cholesterol. This was due to docs within the ’70s
    observing lowered total levels of cholesterol in Anavar customers (15).


    The average bodybuilder will run Anavar for a maximum
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    findings, as most customers are heavier post-Anavar cycle, despite
    dropping notable amounts of subcutaneous fat. Fats
    loss is significant on Anavar, with analysis showing a average dose of 20 mg per day resulting in 4 pounds of fats loss over the course of 12 weeks (4).
    Nonetheless, anecdotally, we have observed further reductions
    in fats mass in our weightlifting patients. Anavar may be prescribed for conditions such as severe weight loss following surgical procedure, persistent sickness,
    or muscle-wasting diseases. It can be utilized in circumstances of hormone imbalances or low testosterone levels.

    Nevertheless, outcomes will in the end vary based on elements like
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    This will assist your physique acclimate to the effects of the remedy and scale back the likelihood of
    side effects. Due to the medication’s capability to increase
    testosterone levels, stereotypically masculine characteristics
    like facial hair and a deeper voice might start to develop.

    Anavar is amongst the hottest steroids available on the market because of its typically good safety profile and absence of great side effects.
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    Beginners and experienced customers can decide totally different cycle
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    Anavar is likely certainly one of the greatest choices for chopping, power, and
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    ❌ Longer cycles improve liver pressure, even though Anavar is among the milder
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    Anavar prevents muscle breakdown, allowing you to retain hard-earned muscle mass whereas shedding physique fats.
    To stop joint issues when utilizing wet AAS compounds, it is essential to use the suitable AI dose (not too high) to handle estradiol levels and prevent excessive water retention. Like Dianabol and Deca Durabolin, cycling Anavar and Anadrol isn’t
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    If the hair loss is extreme enough, there might be permanent shrinkage of the follicles, which prevents your hair from growing again, or it might
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    For sensitive people, hair thinning or shedding
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    Individual response, HGH high quality, dosage, and onerous
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    Nevertheless, this isn't beneficial because of extreme hepatic and renal toxicity.
    Furthermore, by way of advantages, Winstrol will supply some advantages compared to Anavar.
    It has a larger drying impact, most likely because of the reality that winstrol
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    Different girls who’ve taken Anavar need to experience additional fat loss and muscle gains, so
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    For most ladies this can be a big mistake, as Winstrol is very androgenic and thus may be very more doubtless to
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    Cardarine won’t present legal issues as SARMs or other non-anabolic steroid products
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    taking a step back and considering whether or not a substance is a excessive risk.
    Yes, the study used doses which may be well past what
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    Both situations can turn into lifelong issues that would shorten your lifespan. At greater HGH doses, your thyroid can begin being affected with the onset of hypothyroidism.

    For this cause, many HGH customers will also embody T3 in the cycle, as this is a
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    By taking GHRH in its pharmaceutical form, you get a extra even and steady launch of HGH.

    This permits us to gain perception into how totally
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    Throughout testosterone supplementation, the pituitary gland
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    contributing to hypogonadism (3). This process occurs due to supraphysiological levels of
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    Most testosterone esters are suspended in oils like sesame oil or cottonseed oil.
    This offers a slower release of testosterone, so it isn't all used up by the body
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    has been added to testosterone, it turns into much less soluble
    in water and extra soluble in oil. Different esters have a shifting round of atoms to kind very barely completely different compounds from the unique organic compound.

    Pretend anabolic androgenic steroids on the black market – a scientific review and meta-analysis
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    Though women have a fraction of testosterone in comparison with males, it stays an essential hormone of their
    body chemistry. Due to the stimulative effects of clenbuterol, energy and motivation ranges are prone to increase.

    We have discovered the danger of virilization to increase when stacking Anavar and Winstrol collectively.
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    Ideally, testosterone ranges will be measured to observe such bridging.
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